Don't Let Yesterday Take Up Too Much Of Today-4Pain causes lots of changes in the brain. However, there may be noninvasive ways to help stall or reverse some of the damage. According to M. Catherine Bushnell, PhD, scientific director, Division of Intramural Research, National Institutes of Health (NIH), yoga can be an important tool for preventing or even reversing the effects of chronic pain on the brain.

MRI studies in rats and humans have shown alterations in gray matter volume and white matter integrity in the brain caused by the effects of chronic brain. “Imaging studies in multiple types of chronic pain patients show their brains differ from healthy control subjects,” Dr. Bushnell said. “Studies of people with depression show they also have reduced gray matter, and this could contribute to the gray matter changes in pain patients who are depressed. Our research shows that gray matter loss is directly related to the pain when we take depression into account.” The impact of gray matter loss depends on where it occurs in the brain. Decreased gray matter can lead to memory impairment, emotional problems and decreased cognitive functioning.

Dr. Bushnell said there is compelling evidence from studies conducted at NIH and other sites that mind-body techniques, such as yoga and meditation, can counteract the brain anatomy effects of chronic pain. “Practicing yoga has the opposite effect on the brain as does chronic pain,” she said.

Studies show yoga practitioners have more gray matter than controls in multiple brain regions, including those involved in pain modulation. “Some gray matter increases in yogis correspond to duration of yoga practice, which suggests there is a causative link between yoga and gray matter increases,” Dr. Bushnell noted.

She said gray matter changes in the insula or internal structures of the cerebral cortex are most significant for pain tolerance. “Insula gray matter size correlates with pain tolerance, and increases in insula gray matter can result from ongoing yoga practice,” said Dr. Bushnell.

“Brain anatomy changes may contribute to mood disorders and other affective and cognitive comorbidities of chronic pain. The encouraging news for people with chronic pain is mind-body practices seem to exert a protective effect on brain gray matter that counteracts the neuroanatomical effects of chronic pain.”

Practical Pain Management  

July/August  2015


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