Chaotic dynamics play a role in migraine pathophysiology. Chaos also has been a factor in the dynamics of evolution. Humans remain remarkably vulnerable to migraine, with evolutionary factors being the primary reason.
The central nervous system, from the ionic level to neural networks, utilizes chaotic dynamics to some degree. Cortical spreading depression, an integral part of migraine with aura, is likely under chaotic control to some degree. Peripheral and central sensitization are primary pathophysiologic processes in the generation of migraine attacks. These also use chaotic dynamics, at least to some degree.
Chaos, chance, and coincidence are key components of natural selection and evolution. The course of evolution is extremely sensitive to initial conditions, typical for chaotic dynamics. The fractal tree of life follows non-linear dynamics.
To understand why migraine has persisted in Homo sapiens, we must look through an evolutionary lens. There are a number of genes involved in migraine. Evolution does not possess efficient means with which to delete harmful genes.
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