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Preventive Treatment of Migraine: Effect on Weight
Young WB, Rozen TD.
Posted: January 2006  
Cephalalgia 2005;25:1-11

Weight gain is a side effect commonly associated with drugs used for headache prophylaxis. Weight gain can adversely affect patient health, exacerbate comorbid metabolic disorders, and encourage noncompliance. Few studies have been conducted specifically on the effect of headache medications on weight, and it is important for physicians to have accurate information about weight-gain side effects when identifying appropriate pharmacological regimens. This review discusses the potential effects on weight of the more common headache medications.