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Long-Term Tolerability of Sumatriptan
Nasal Spray in Adolescent Patients With Migraine
Natarajan S, Jabbour JT, Webster CJ, Richardson, MS.
Posted: January 2005  
Headache 2004;44:969-977

Objective:  This one-year, open-label, multicenter study was designed to assess the long-term tolerability and efficacy of sumatriptan nasal spray 20 mg. in adolescent patients with migraine.

Methods:  A prospective, multicenter, open-label study was conducted in patients aged 12 to 17 years who were allowed to treat an unlimited number of migraines at severe, moderate, or mild pain intensity with sumatriptan nasal spray for up to 1 year. All patients started the study at the 20 mg. dose of sumatriptan nasal spray. Dose could be adjusted downward to 5 mg. at the discretion of the investigator to optimize therapy.

Conclusion:  Sumatriptan nasal spray 20 mg. is generally well tolerated and may be beneficial during long-term use by adolescent migraineurs ages 12 to 17 years.