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Effect of Divalproex on Metabolic Parameters is Dose
Related in Migraine Prophylaxis
Green MW, Giordano S, Jiang P, Jafari M, Smith TB
Posted: November 2005  
Headache 2005;45:1031-1037

Objective:  To examine the metabolic effects of three divalproex dosing regimens in patients with migraine.

Background:  Epidemiological and clinical studies have demonstrated a strong association between serum lipid levels and the development of coronary artery disease. Thus, it is important to understand the impact of chronically administered medications on serum lipids. Metabolic properties of divalproex, an approved and commonly used treatment for migraine prophylaxis, have not been systematically studied in patients with migraine.

Conclusions:  Divalproex results in a dose-dependent reduction in serum cholesterol within the first 3 months of therapy, with no significant change in serum glucose of BMI.