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Efficacy of Coenzyme Q10 in Migraine Prophylaxis: A
Randomized Controlled Trial
Sandor PS, Clemente LD, et al.
Posted: November 2005  
Neurology 2005;64:713-715

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack frequency, headache days and days with nausea in the third treatment month and well tolerated; 50% responder rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10. CoQ10 is efficacious and well tolerated.