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Migraine Prevalence During Menopausal Transition
Shuu-Jiun Wang, MD; Jong-Ling Fuh, MD, et al.
Posted: July 2003
Headache 2003;43:470-478
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Background: The effect of menopausal transition on the frequency of migraine has never been the focus of a community-based study.
Methods: A cross-sectional community-based survey was undertaken among Chinese women aged 40 to 54 years in Taiwan. Neurologists diagnosed migraine based on the 1988 International Headache Society classification criteria. Menstrual history including a past or current history of premenstrual syndrome was obtained. Serum levels of estradiol and follicle-stimulating hormone were measured.
Conclusions: Our data supported the clinical impression that migraine prevalence increased before menopause and declines after spontaneous menopause. However, in this study, this trend occurred only in women with increased vulnerability to hormonal change, such as those with premenstrual syndrome. The presence of low estrogen and high follicle-stimulating hormone levels predicted lower migraine prevalence, whereas a history of hysterectomy was related to higher prevalence.
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