The Efficacy of Divalproex Sodium in the Prophylactic Treatment of Children With Migraine


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The Efficacy of Divalproex Sodium in the Prophylactic
Treatment of Children With Migraine
JMCaruso, DO; WBrown, MD; GExil, MD; GGascon, MD
Posted Nov 2000
HEADACHE, September 2000

Objective: To determine the beneficial use of divalproex sodium as a prophylactic treatment for migraine in children.

Results: A total of 42 patients, ranging in age from 7 to 16 years (mean age, 11.3 years), were treated with divalproex sodium for headache. All had a history of migraine with or without aura. Baseline headache frequency during a minimum 6-month period was one to four headaches per month. Of the 42 patients, 34 (80.9%) successfully discontinued their abortive medications. After 4 months’ treatment, 50% headache reduction was seen in 78.5% of patients, 75% reduction in 14.2% of patients, and 9.5% of patients became headache-free.

Conclusion: Results indicate divalproex sodium to be an effective and well-tolerated treatment for the prophylaxis of migraine in children.

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