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Demographic and Migraine Characteristics of Adolescents
with Migraine: Glaxo Wellcome Clinical Trials’ Database
P Winner, DO; AD Rothner, MD; et al.
Posted: July 2003
Headache:2003; 43:451-457
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Objective: To describe the demographics and migraine characteristics of patients in the Glaxo Wellcome adolescent clinical trials’ database.
Methods: Data from 8 sumatriptan (tablet and nasal spray) and naratriptan (tablet) trials (6 placebo controlled and 2 open label) were reviewed. Adolescents aged 12 to 17 years who had participated in migraine clinical trials and used at least 1 dose of study medication were summarized using descriptive statistics. Patient demographic (gender, age, race, height, and weight) and migraine (diagnosis, pain location and intensity, time and day of migraine onset and treatment, and associated symptoms) characteristics were examined.
Conclusions: In this large clinical trials’ database, adolescents had migraine without aura characterized by unilateral and pulsating pain and aggravated by activity. The incidence of associated symptoms was directly related to pretreatment pain intensity. More migraines occurred Monday through Wednesday during typical school hours. These data may facilitate clinicians’ efforts to tailor migraine therapy to the needs of this patient population.
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